Serdyuk V.N.^1,2, Klopotskaya N.G.¹, Ustimenko S.B.², Tarnopol’skaya I.N.², Maydenko E.N.², Klopotskaya E.P.¹

¹SE «Dnipropetrovsk Medical Academy of Health Ministry of Ukraine», Dnipro, Ukraine
²CE «Dnipropetrovsk Regional Clinical Ophthalmologic Hospital», Dnipro, Ukraine

Summary. Traumatic uveitis after penetrating eye injury is known to have multifactorial nature: its development is caused by cell membrane destruction, antioxidant enzymes deficiency, accumulation of nitrogen oxidation products, eye hypoxia, release of cytokines in particular interleukins (IL), etc. So use of cytokines inhibitors or blockers is considered to be a perspective way of traumatic uveitis treatment. Researches in recent years showed ability of ectoine to stabilize biological membranes, reduce the IL and prostaglandins production, normalize the nitric oxide level and inhibit cell signaling system.

Aim of the work. To study the effectiveness of ectoine use in the complex treatment of children with traumatic uveitis.

Methods. We observed 14 children of the main group and 10 of the control group with aseptic uveitis after penetrating eye injury. The groups were identical in patients’ age and clinical manifestations. Besides of routine clinical examination we examined the blood level of IL-1 and C-reactive protein (CRP) that is known to be released in liver under the action of IL-1. All the examinations were performed at the 1st and 8th day after trauma. All the children got complex treatment but patients of the main group were prescribed additionally instillations of 2% solution of ectoine (ЕYE-t Ectoine Pro) 8 times per day.

Results. Before treatment the blood levels of IL-1 and CRP in our patients were more than 3.5 times worse than in healthy persons both in the main and the control group. In a week after the therapy had started we observed clinical improvement in the both groups. In the main group IL-1 level decreased from 86.8 ± 4.1 to 52.8 ± 9.1 pg/ml (P<0.005), in the control one from 86.6 ± 5.5 to 77.2 ± 1.3 (P<0.2). Reliability of difference between the groups was P<0,05. CRP level decreased in the main group from 9.8 ± 1.4 to 4.7 ± 0.3 mg/l, in the control one from 9.7 ± 0.6 to 7.1 ± 0.4 (P<0.005). Difference between the groups was reliable (P<0.001). Any allergic reactions and side effects were not observed.

Conclusions. Use of ectoine 2% solution lets improve effectiveness of traumatic uveitis treatment, is safe, pathogenetically reasonable and can be recommended in complex therapy of children with penetrating eye injury.

Keywords: traumatic uveitis, penetrating injury of eye, children, ectoine.

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Received: 21 Oct. 2016

Published: April 2017