Remote monitoring of progression of retinopathy in patients with juvenile diabetes mellitus and different thyroid dysfunction

Nedzvetska O.V.¹, Yavtushenko L.A.², Budreiko Ye.A.³, Chumak S.A.³

¹Kharkiv medical academy of postgraduate education, Kharkiv, Ukraine

²Municipal L. L. Hirshman hospital № 14, Kharkiv, Ukraine

³SI «Institute of Children and Adolescents Health Care of NAMS of Ukraine», Kharkiv, Ukraine

Summary. The aim of the work was to study the dependence of the dynamics of juvenile diabetic retinopathy (JDR) progression in patients with juvenile diabetes mellitus (JDM) type 1 flowing against various distireozis. The paper presents the results of elevenyear JDR monitoring study in patients with JDM type 1 flowing against various distireozis. There were 3 groups: the group 1 – patients with JDM without thyroid dysfunction, the group 2 – JDM with the increased level of TTG, the group 3 – JDM with autoimmune thyriditis (AIT). The examination included the visual acuity testing, biomicroophthalmoscopy, the photoregistration by means of the fundus camera TRC-NW7SF «Topcon» (Japan). The optic coherent tomography was used in the regimen of «Macula thickness» (OptoVue-100). Thyroid-stimulating hormone (TSH) level was determined by radioimmunological method.

 It was found that during the first five years of follow-number of eyes with nonproliferative diabetic retinopathy (NPDR) in patients with JDM type 1 and with thyropathy (TP) with elevated TSH level increased by 17.6 %, in groups without TP and with autoimmune thyroiditis (AIT) – 9.7 and 9.4 %; after eleven years of observation the number of eyes with NPDR in patients with JDM type 1 and with TP with elevated TSH level increased by 36.0 %, while in groups without TP and with AIT – 21.6 and 22.2 %. Start of proliferative changes in the eye fundus in patients with JDM type 1 and with TP with elevated TSH level occurs at an earlier stage (9,27 ± 2,16 years) from the onset of the disease compared with the group without TP (14,28 ± 2,13 years) and with AIT (13,67 ± 1,52 years).

 Concomitant diabetes TP with elevated TTH level contributes to an earlier and more pronounced JDR progression, compared with JDM without thyroid pathology or with autoimmune thyroiditis, which is manifested by almost 2 times higher incidence of NPDR and PDR.

 Keywords: juvenile diabetic retinopathy, juvenile diabetes melitus, thyropathy.

Our experience using of plication for treatment of strabismus

Serdiuk V. N.¹, Klopotska N. H.², Tarnopolska I. N.¹, Petrenko Ye. A.¹, Tykhomyrova V. V.¹

¹Dnipropetrovsk Regional Clinical Eye Hospital of Dnipropetrovsk Regional Council, Dnipropetrovsk, Ukraine

²Dnipropetrovsk Medical Academy, Dnipropetrovsk, Ukraine

Summary. Plication is a way to strengthen the muscle in strabismus by creating muscular folds of the middle third of the muscle. Aim is to investigate the plication effectiveness in different types of strabismus in children. Plication was performed in 19 children with concomitant strabismus, 3 with traumatic and 1 with paralytic strabismus due to n. abducens lesion. Plication was performed as a separate operation (in case of second surgical treatment) or in combination with the recession of antagonist muscle. In 3–4 days after surgery complete elimination of the angle of strabismus was observed in 19 children (82.6 %). A year later recurrence of strabismus was observed in 3 patients. Binocular vision was recovered in 13 patients (59.1 %). The worst results were observed in cases of paralytic strabismus and concomitant strabismus with large angles of deviation and low visual functions. Plication is easily doable effective operation for treatment of strabismus in children.

Keywords: children, strabismus, surgery, plication.

Efficacy, tolerability and safety of tafluprost ophthalmic solution in glaucoma

Havryliuk T.I.¹, Danovska V.M.², Yanenko V.O.³

¹Cherkasy Regional Hospital, Cherkasy, Ukraine

²Second Cherkasy Clinic, Cherkasy, Ukraine

³Rigional Territorial Medical Association, Gorodishche, Ukraine

Summary. This article provides information about the efficacy, tolerability and safety of eye drops 0.0015 % tafluprost (Taflotan®, Santen, Finland) for the treatment of patients with glaucoma. Control of intraocular pressure (IOP) during the study was carried out at baseline and at 4–6 and 12 weeks after the start of application of eye drops Taflotan®. Also was еvаluаted the tolerability and safety of the drug. In primary open angle glaucoma after 12 weeks of monotherapy with tafluprost or combined treatment with tafluprost and beta-blockers showed a significant decrease in IOP. When pseudoexfoliative and pigmentary glaucoma, a significant reduction in IOP was recorded as in tafluprost monotherapy and combined treatment. In objective assessment of the impact of the drug on the surface of the eye Taflotan® shown that the prescription of tafluprost preservative-free not registered conjunctival hyperemia and the lack of negative influence in any of the surveyed patients.

It was found that the application of eye drops without preservative products Taflotan® tears and tear film stability remained normal throughout the period of treatment and observation. In the group of patients treated with Taflotan® preservative in the vial with a slight decrease tear secretion, tear film stability which were compensated with the additional purpose lubricants. Most patients rated tolerance of eye drops Taflotan® as «excellent» and «good».

Keywords: glaucoma, intraocular pressure, tafluprost, portability, security applications.

Character binocular field of vision and quality of life in patients with primary open-angle glaucoma

 Bezditko P.A., Stoliarova Ye.K.

Kharkiv National Medical University, Kharkiv, Ukraine

 Summary. Glaucoma is one of the most important problems of ophthalmology. Primarily glaucoma affects the quality of life because it leads to the loss of the visual field. The reasons for late visit to an ophthalmologist, a relatively small number of cases of open-angle glaucoma detected in early stage, high level of disability – are the important issues of ophthalmology. Life quality assesments, the second important indicator, which allows you to obtain information about the value and importance of the constraints that result from the disease. Purpose is to get more strict representation about the visual field of the patient to  the binocular visual sensitivity and to appreciate the degree of changes due to diseases of the patient with Esterman test and comparison with the data of the visual field examination.

The article presents the results of study of the changes occurring in the binocular field of vision in patients with primary open-angle glaucoma in comparison with changes in the monocular visual field and quality of life. The features of the influence of primary open-angle glaucoma in the quality of life of patients and the possible reasons for delays in seeking medical attention.

It is shown that open-angle glaucoma mostly affects the ability to perform tasks that require binocular field of view than the tasks for which the binocular field of view does not really matter. Therefore, in determining admission to the performance the work with special conditions (driving a car, work with machines, and so on) patients should be examined according to their condition of binocular visual field.

Keywords: open-angle glaucoma, quality of life, monocular visual field, binocular visual field.