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The dynamics of cell type uveal melanoma in Kharkiv region for the last 30 years

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Written by Super User
Category: #1 (06) 2017
Published: 05 March 2018
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Panchenko M., Honchar O., Prykhodko D., Pereiaslova H.


Kharkiv National Medical University, Kharkiv, Ukraine
Kharkiv Regional Clinical Hospital, Kharkiv, Ukraine

Summary. Uveal melanoma is one of the most common primary intraocular malignancy in adult patients (Mouriaux F., 2014).

The objective of the investigation was to study the dynamics of cell type of uveal melanoma in Kharkiv region in the last 30 years.

Materials and Methods. The results of histological investigations of uveal melanoma were analyzed in 82 patients (33 male and 49 female) aged from 28 to 86 years having been treated in ophthalmology department of Kharkiv regional clinical hospital from 1985 to 2015 years. The cell type tumor was determined according to the modified Callender’s classification.

Results. The conducted research proved, that the average age of the patients was 61.2 years. The spindle cell melanoma was diagnosed in 29 patients (35.4 %), epithelioid cell type was in 24 (29.3 %) and mixed cell type – in 27 (32,9 %). The necrosis of tumor was revealed in two patients. The percentage of patients with epithelioid cells in 1985 – 1994 and in 1995 – 2004 years was about the same (61.9 % and 59.5 % respectively), but in 2005 – 2015 some increase was noticed up to 68.4 %. The comparison of indexes in the periods from 1985 to 2000 and from 2001 to 2015 years proved the increase of epithelioid cells melanoma from 59.6 % to 65 %.

Conclusions. In the last 15 years the increase of epithelioid cells melanoma from 59,6 % to 65 % was fixed in Kharkiv region, and in the last 10 years respectfully – up to 68.4 %. In dynamics in the last 15 years the average age of patients with uveal melanoma increased from 57.8 to 65.6 years in Kharkiv region.

Keywords: uveal melanoma, cell type, dynamics for 30 years.

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Received: 11 Nov. 2016

Published: April 2017