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The dynamics of cell type uveal melanoma in Kharkiv region for the last 30 years

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Written by Super User
Category: #1 (06) 2017
Published: 05 March 2018
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Panchenko M., Honchar O., Prykhodko D., Pereiaslova H.


Kharkiv National Medical University, Kharkiv, Ukraine
Kharkiv Regional Clinical Hospital, Kharkiv, Ukraine

Summary. Uveal melanoma is one of the most common primary intraocular malignancy in adult patients (Mouriaux F., 2014).

The objective of the investigation was to study the dynamics of cell type of uveal melanoma in Kharkiv region in the last 30 years.

Materials and Methods. The results of histological investigations of uveal melanoma were analyzed in 82 patients (33 male and 49 female) aged from 28 to 86 years having been treated in ophthalmology department of Kharkiv regional clinical hospital from 1985 to 2015 years. The cell type tumor was determined according to the modified Callender’s classification.

Results. The conducted research proved, that the average age of the patients was 61.2 years. The spindle cell melanoma was diagnosed in 29 patients (35.4 %), epithelioid cell type was in 24 (29.3 %) and mixed cell type – in 27 (32,9 %). The necrosis of tumor was revealed in two patients. The percentage of patients with epithelioid cells in 1985 – 1994 and in 1995 – 2004 years was about the same (61.9 % and 59.5 % respectively), but in 2005 – 2015 some increase was noticed up to 68.4 %. The comparison of indexes in the periods from 1985 to 2000 and from 2001 to 2015 years proved the increase of epithelioid cells melanoma from 59.6 % to 65 %.

Conclusions. In the last 15 years the increase of epithelioid cells melanoma from 59,6 % to 65 % was fixed in Kharkiv region, and in the last 10 years respectfully – up to 68.4 %. In dynamics in the last 15 years the average age of patients with uveal melanoma increased from 57.8 to 65.6 years in Kharkiv region.

Keywords: uveal melanoma, cell type, dynamics for 30 years.

REFERENCES

  1. Albert D.M. Histopathologic characteristics of uveal melanomas in eyes enucleated from the collaborative ocular melanoma study COMS report no. 6 / D.M. Albert, M. Diener-West, N.L. Robinson [et al.] // Am. J.Ophthalmol. – 1998. – Vol. 125, №6. – P. 745 – 766.
  2. Asnaghi L. EMT-associated factors promote invasive properties of uveal melanoma cells /L. Asnaghi, G. Gezgin, A. Tripathy [et al.] // Mol. Vis. – 2015. – Vol. 21. – P. 919 – 929.
  3. Augsburger J.J. An alternative hypothesis for observed mortality rates due to metastasis after treatment of choroidal melanomas of different sizes / J.J. Augsburger, Z.M. Corrêa, N. Tricho poulos // Trans. Am. Ophthalmol. Soc. – 2007. – Vol. 105. – P. 54 – 60.
  4. Bagger M. The prognostic effect of American Joint Committee on Cancer staging and genetic status in patients with choroidal and ciliary body melanoma / M. Bagger, M.T. Andersen, K.K. Andersen [et al.] // Invest. Ophthalmol. Vis. Sci. – 2015. – Vol. 56. – P. 438 – 444.
  5. Bagger M. Transviteral Retinochoroidal Biopsy Provides a Representative Sample From Choroidal Melanoma for Detection of Chromosome 3 Aberrations / M. Bagger, M.T. Andersen, S. Heegaard [et al.] // Invest. Ophthalmol. Vis. Sci. – 2015. – Vol. 56, 10. – P. 5917 – 5924.
  6. Bergman L. Uveal melanoma survival in Sweden from 1960 to 1998 / L. Bergman, S. Seregard, B. Nilsson [et al.] // Invest. Ophthalmol. Vis. Sci. – 2003. – Vol. 44. – P. 3282 – 3287.
  7. Biswas J. Clinical and Histopathological Characteristics of Uveal Melanoma in Asian Indians. A Study of 103 Patients / J. Biswas, S. Kabra, S. Krishnakumar, M.P. Shanmugam //Indian J. Ophthalmol. – 2004. – Vol. 52. – P. 41 – 44.
  8. Callender G.R. Five hundred melanomas of the choroid and ciliary body followed five years or longer / G.R. Callender, H.C. Wilder, J.E. Ash // Am. J. Ophthalmol. – 1942. – Vol. 25. –P. 962 – 967.
  9. Callender G.R. Malignant melanotic tumors of the eye: a study of histologic types in 111 cases / G.R. Callender // Am. Acad. Ophthalmol. Otolaryngol. – 1931. – Vol. 36. – P. 131 – 140.
  10. Damato B. A reappraisal of the significance of largest basal diameter of posterior uveal melanoma / B. Damato, S.E. Coupland // Eye (Lond.) – 2009. – Vol. 23, 12. – P. 2152 – 2160.
  11. Damato B. Cytogenetics of uveal melanoma: a 7-year clinical experience / B. Damato, C. Duke, S.E. Coupland [et al.] // Ophthalmology – 2007. – Vol. 114. – P. 1925 – 1931.
  12. Damato B. Estimating prognosis for survival after treatment of choroidal melanoma /B. Damato, A. Eleuteri, A.F. Taktak, S.E. Coupland // Prog. Retin. Eye Res. - 2011. - Vol.30.- P. 285 - 295.
  13. Damato B. Legasy of the Collaborative Ocular Melanoma Study / B. Damato // Arch. Ophthalmol. – 2007. – Vol. 125, 7. – P. 966 – 968.
  14. Eskelin S. Tumor doubling times in metastatic malignant melanoma of the uvea: tumor progression before and after treatment / S. Eskelin, S. Pyrhonen, P. Summanen [et al.] //Ophthalmology. – 2000. – Vol. 107. – P. 1443 – 1449.
  15. Field M.G. Resent developments in prognosis and predictive testing in uveal melanoma /M.G. Field, J.W. Harbour // Curr. Opin. Ophthalmol. – 2014. – Vol. 25, 3. – P. 234 – 239.
  16. Fuchs U. An immunohistochemical and prognostic analysis of cytokeratin expression in malignant uveal melanoma / U. Fuchs, T. Kivela, P. Summanen [et al.] // Am. J. Pathol. –1992. – Vol. 141, 1. – P. 169 – 181.
  17. Gupta P.B. The melanocyte differentiation program predisposes to metastasis after neoplastic trans formation / P.B. Gupta, C. Kuperwasser, J.P. Brunet [et al.] // Nat. Genet. – 2005. – Vol. 37. – P. 1047 – 1054.
  18. Harbour J.W. A prognostic test to predict the risk of metastasis in uveal melanoma based on 15-gene expression profile / J.W. Harbour // Methods Mol. Biol. – 2014. – Vol. 1102. –P. 427 – 440.
  19. Harbour J.W. Eye cancer: unique insights into oncogenesis: the Cogan Lecture / J.W. Harbour // Invest.  Ophthalmol. Vis. Sci. – 2006. – Vol. 47. – P. 1736 – 1745.
  20. Hay E.D. The mesenchymal cell, its role in the embryo, and the remarkable signaling mecha nisms that create it / E.D. Hay // Dev. Dyn. – 2005. – Vol. 233. – P. 706 – 720.
  21. Hoek K. Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas / K. Hoek, D.L. Rimm, K.R. Williams [et al.] // Cancer Res. - 2004. - Vol. 64. - P. 5270-5282.
  22. Jensen O.A. Malignant melanomas of the human uvea: 25-year followup of cases in Denmark, 1943–1952 / O.A. Jensen // Acta. Ophthalmol. (Copenh.) – 1982. – Vol. 60. – P. 161 - 182.
  23. Johansson C.C. Expression and prognostic significance of iNOS in uveal melanoma /C.C. Johansson, D. Mougiakakos, E. Trocme [et al.] // Int. J. Cancer. – 2010. – Vol. 126. –P. 2682 – 2689.
  24. Kivela T. Prognostication in eye cancer: the latest tumor, node, metastasis classification and beyond / T. Kivela, E. Kujala // Eye – 2013. – Vol. 27. – P. 243 – 252.
  25. Kujala E. Very long-term prognosis of patients with malignant uveal melanoma / E. Kujala, T. Makitie, T. Kivela // Invest. Ophtalmol. Vis. Sci. – 2003. – Vol. 44. – P. 4651 – 4659.
  26. Laver N.V. Ocular melanoma / N.V. Laver, M.E. McLaughlin, J.S. Duker // Arch. Pathol. Lab. Med. – 2010. – Vol. 134. – P. 1778 – 1784.
  27. Mouriaux F. Increased HIF-1α expression correlates with cell proliferation and vascular markers CD31 and VEGF-A in uveal melanoma / F. Mouriaux, F. Sanschagrin, C. Diorio [et al.] // Invest. Ophthalmol. Vis. Sci. – 2014. – Vol. 55, 3. – P. 1277 – 1283.
  28. Onken M.D. An accurate,clinically feasible multigene expression assay for predicting metastasis in uveal melanoma / M.D. Onken, L.A. Worley, M.D. Tuscan, J.W. Harbour // J. Mol. Diagn. – 2010. – Vol. 12. – P. 461 – 468.
  29. Onken M.D. Gene Expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death / M.D. Onken, L.A. Worley, J.P. Ehlers, J.W. Harbour // Canser Res. – 2004. – Vol. 64. – P. 7205 – 7209.
  30. Paul E.V. Prognosis of malignant melanomas of the choroid and ciliary body / E.V. Paul, B.L. Parnell, M. Fraker // Int. Ophthalmol. Clin. – 1962. – Vol. 2. – P. 387 – 402.
  31. Polyak K. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits / K. Polyak, R.A. Weinberg // Nat. Rev. Cancer – 2009. – Vol. 9. – P. 265 – 273.
  32. Qu Y. Overexpression of high mobility group A1 protein in human uveal melanomas: implication for prognosis / Y. Qu, Y. Wang, J. Ma [et al.] – Available from: http://journals.plos.org/plosone/article.
  33. Rietschel P. Variates of survival in metastatic uveal melanoma / P. Rietschel, K.S. Pana geas, C. Hanlon [et al.] // J. Clin. Oncol. – 2005. – Vol. 23. – P. 8076 – 8080
  34. Scholes A.G. Monosomy 3 in uveal melanoma: correlation with clinical and histologic predictors of survival / A.G. Scholes, B.E.  Damato, J. Nunn [et al.] // Invest. Ophthalmol. Vis. Sci. – 2003. – Vol. 44. – P. 1008 – 1011.
  35. Shields C.L. Prognosis of uveal melanoma in 500 cases using genetic testing of fine-needle aspiration biopsy specimens / C.L. Shields, A. Ganguly, C.G. Bianciotto [et al.] // Ophthalmology. – 2011. – Vol. 118. – P. 396 – 401.
  36. Sibbritt T. Mapping and significance of the mRNA methylome / T. Sibbritt, H.R.  Patel, T. Preiss // Wiley Interdiscip. Rev. RNA – 2013. – Vol. 15, 4. – P. 397–422.
  37. Singh A.D. Survival rates with uveal melanoma in the United States: 1973–1997 /A.D. Singh, A. Topham // Ophthalmology – 2003. – Vol. 110. – P. 962 – 965.
  38. Singh A.D. Uveal melanoma: trends in incidence, treatment, and survival / A.D. Singh, M.E. Turell, A.K. Topham // Ophthalmology. – 2011. – Vol. 118. – P. 1881 – 1885.
  39. Thiery J.P. Epithelial-mesenchymal transitions in development and disease / J.P. Thiery, H. Acloque, R.Y. Huang, M.A. Nieto // Cell. – 2009. – Vol. 139. – P. 871 – 890.
  40. Toth J. Retrospective study on uveal melanoma / J. Toth // Hungarian Oncology – 2005. –Vol. 49. – P. 19–25.
  41. Triozzi P.L. Targeted therapy for uveal melanoma / P.L. Triozzi, C. Eng, A.D. Singh // Cancer Treat. Rev. - 2008. - Vol. 34. – P. 247 – 258.
  42. Vaarwater J. Multiplex ligation-dependent probe amplification equals fluorescence in situ hybridization for the identification of patients at risk for metastatic disease in uveal melanoma / J. Vaarwater, T. van den Bosch, H.W. Mensink [et al.] // Melanoma Res. – 2012. –Vol. 22. – P. 30 – 37.
  43. Yang J. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis / J. Yang, R.A. Weinberg // Dev. Cell. – 2008. – Vol. 14. – P. 818 – 829.
  44. Zhang Y. Expression analysis of genes and pathways associated with liver metastases of the uveal melanoma / Y. Zhang, Y. Yang, L. Chen, J. Zhang // BMC Med. Genet. – 2014. – Vol. 15.

Received: 11 Nov. 2016

Published: April 2017