Serdyuk V., Іshchenko V.

Dnipropetrovsk Regional Clinical Ophthalmology Hospital, Dnipro, Ukraine 

Summary

Background. Leptin is a hormone that regulates food intake, In vitro and in vivo assays revealed that leptin has angiogenic activity. Observations indicated that the vascular endothelium is a target for leptin. Objective. There were investigated the leptin levels in the blood of 80 patients with type 2 diabetes mellitus (DM2) (mean age 58.20±0.99 years, the average length of diabetes 9.19±0.16 years, the average level of glycated hemoglobin (HbA_1C) 9.10±0.16 %) at different stages of diabetic retinopathy (DR). Methods. The ANOVA was used as statistical analysis. Results. There were obtained significant differences (P = 0.03) between the group of patients at 1 stage of DR (17.25±3.14 ng/ml) under the age of 60 years compared with a group of patients aged over 60 years at 2+3 stages of DR (33.97±4.94 ng/ml). The intermediate levels of leptin in patients at 2+3 stages of DR with diabetes experience more than 10 years (33.75±5.58 ng/ml) was higher (P = 0.05) compared with the same index in patients at 1 stage of DR with a length of diabetes up to 10 years (17.05±2.80 ng/ml). Conclusion. The emergence of non-proliferative stage of DR comes on the background of persistent hyperleptinemia. The development of the proliferative stage of DR is associated with a statistically significant leptin resistance in patients from the older age group and from the group with duration of DM2 more than 10 years.

Keywords: diabetic retinopathy, obesity, leptin.

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Received: 23 Jan. 2017

Published: April 2017