ENTER


Полный размерЗакрыть

Bacterial keratitis: pathogenesis and treatment

Details
Written by Super User
Category: #2 (07) 2017
Published: 18 April 2018
Hits: 2308

https://doi.org/10.30702/Ophthalmology.2017/07.art10

 Sakovych V. N.1, Volok S. I.2, Malik L. P.2, Isaev A. A.1


1Dnipropetrovsk Medical Academy of Ministry Health of Ukraine, Dnipro, Ukraine
2Dnipropetrovsk Regional Clinical Ophthalmology Hospital, Dnipro, Ukraine

 Summary. The article is devoted to the issue of pathogenesis and treatment of eyes with bacterial keratitis, depending on pathogenetic features and type of pathogens. The results of the works presented in the literature indicate an increasing number of bacterial keratitis with resistance to the therapy. Also, the appearance in recent years of strains of bacteria that are resistant to many antibiotics used in medical practice has significantly worsened the positive dynamics for the standard treatment regimens used. And the problem of evolutionary changes in the structure of pathogens and their biological properties dictates the need for clinical and microbiological monitoring, which can provide an adequate range of therapeutic and preventive measures.

 Keywords: bacterial keratitis, pathogenesis, treatment.

REFERENCES

  1. Maurice DM. The structure and transparency of the cornea. J Physiol. 1997;136:263–274.
  2. Reddy M, Sharma S, Rao GN. Corneal ulcer. In: Dutta LC, editor. Modern Ophthalmology. 2nd ed. New Delhi: Jaypee Brothers Medical Publishers; 2000. p. 200−16.
  3. Hazlett LD. Role of innate and adaptive immunity in the pathogenesis of keratitis. Ocul. Immunol. Inflamm. 2005;13(2–3):133–138.
  4. Kansky DD. [Clinical ophthalmology: a systematic approach]. Moscow: Logosfera; 2006. 744 р. (in Russian).
  5. Suzuki T, Kawamura Y, Uno T, et al. Prevalence of Staphylococcus epidermidis strains with biofilm-forming ability in isolates from conjunctiva and facial skin. Am. J. Ophthalmol. 2005;140(5):844–850.
  6. Saldan VI, Young AL. [Species composition of microflora in infectious diseases of the anterior part of the eye]. Proceedings of the Scientific-practical Conf. with intern. “New in Ophthalmologyˮ; 2005 May 13; Odessa, Ukraine. Odessa; 2005. p. 35–36. (in Russian).
  7. Chandrasekher G, Ma X, Lallier ТЕ, Bazan HE. Delay of corneal epithelial wound healing and induction of keratocyte apoptosis by platelet-activating factor. Invest. Ophthalmol. Vis Sci. 2000;43(5):1422–1428.
  8. Elner VM, Strieter RM, Pavilack MA, et al. Human corneal interleukin-8. IL-1 and TNFinduced gene expression and secretion. Am. J. Pathol. 1991;139:977–988.
  9. Shaimova VA. Clinico-etiological features of different types of purulent corneal ulcer course. Herald of Ophthalmology. 2002;1:39–41.
  10. Goldman JN, Benedek GB. The relationship between morphology and transparency in the non-swelling corneal stroma of the shark. Invest Ophthalmol. 1997;42(7):1334−1340.
  11. Maychuk YF. Algorithm of therapy of bacterial conjunctivitis and keratitis. Directory of the polyclinic. 2005;4:73–76.
  12. Callegan MC, Booth MC, Gilmore MS. In vitro pharmacodynamics of ofloxacin and ciprofloxacin against common ocular pathogens. Cornea. 2000;19(4):539–545.
  13. Bryant K, Chang T, Chen S, Rosenberg J, Hammond R, McConnell K, et al. Acanthamoeba keratitis − multiple states, 2005–2007. Morbidity and Mortality Weekly Report. 2007; 56: 532–4.
  14. Constantinou M, Daniell M, Snibson GR, et al. Clinical efficacy of moxifloxacin in the treatment of bacterial keratitis: a randomized clinical trial. Ophthalmology. 2007;114:1622–9.
  15. Ermis SS, Aktepe OC, Inan UU, Ozturk F, et al. Effect of topical dexamethasone and ciprofloxacin on bacterial flora of healthy conjunctiva. Eye. 2004;18(3):249–52.
  16. Hwang DG. Fluoroquinolone resistance in ophthalmology and the potential role for newer ophthalmic fluoroquinolones. Surg. Ophthalmol. 2004;49(2):79–83.
  17. Mino de Kaspar H, Kreutzer TG, Aguirre-Romo I. A prospective randomized study to determine the efficacy of preoperative topical; levofloxacin in reducing: conjunctival bacterial flora. Am. J. Ophthalmol. 2008;145(1):136–42.
  18. Lofoco G, Quercioli P, Ciucci F. Fusidic acid vs ofloxacin prophylaxis before cataract surgery. Eur. J. Ophthalmol. 2005;15(6):718–21.
  19. Di Iorio E, Barbaro V, Ruzza A, et al. Isoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regeneration. Proc. Natl. Acad Sci USA. 2005;102(27):9523–8.
  20. Jan AV, Novikov SA, Doubaysi IN. [Operation of pancorneal coagulation in the treatment of endothelial-epithelial dystrophy of the cornea: long-term results and development prospects]. Proceedings of the 8th Congress of ophthalmologists of Russia; 2005 Jun 1−4; Moscow, Russia. Moscow; 2005. p. 488–489. (in Russian).
  21. Abshire R, Cockrum P, Crider J. Topical antibacterial therapy for mycobacterial keratitis: potential for surgical profhylaxis and treatment. Clin. Ther. 2004;26(2):191–196.
  22. Sudalin AB, Batmanov JE. The use of keratoplasty and conjunctival plastics in the treatment of deep keratitis. Klinich. Ophthalmology. 2003;4(1):1–3.
  23. van Dooren BT, Mulder PG, Nieuwendaal CP, Beekhuis WH, Melles GR. Endothelial cell density after deep anterior lamellar keratoplasty (Melles technique). Am. J. Ophthalmol. 2004;37:397–400.
  24. Sukhija J, Jain AK. Outcome of therapeutic penetrating keratoplasty in infectious keratitis. Ophthalmic. Surg. Lasers Imaging. 2005;36(4):303–9.
  25. Lin PY, Wu CC, Lee SM. Combined phototherapeutic keratectomy and therapeutic contact lens for recurrent erosions in bullous keratopathy. Br. J. Ophthalmol. 2001;85:908–911.

Received:19 June 2017

Published: December 2017