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24-h IOP control with latanoprost, travoprost, and bimatoprost in subjects with exfoliation syndrome and ocular hypertension

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Written by Super User
Category: #1 (08) 2018
Published: 16 October 2018
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Hepsen I. F.1, Ozkaya E.2


1Fatih University Medical School, Ankara, Turkey
2Inonu University Medical School, Malatya, Turkey

ABSTRACT

Purpose. To compare the 24-h IOP reductions induced by latanoprost, travoprost, and bimatoprost in eyes with exfoliation syndrome (XFS) associated with ocular hypertension (OH).

Methods. This was a prospective, randomized, single masked, and parallel design study with 15 patients in each treatment group. After washout of any previous medications, each patient underwent a baseline 24-h IOP curve testing at 06:00, 09:00, 12:00, 15:00, 18:00, 21:00, and at 24:00 (midnight) hours. Patients were then randomized to receive latanoprost, travoprost, or bimatoprost once a day for 3 months. The 24-h curve testing was repeated at first week, and first and third months.

Results. Maximal and minimal IOP was recorded at 06:00 and 18:00–21:00 hours. There was no significant difference among treatment groups at any time-point except for the first week. At the first week, the travoprost group had significantly lower IOP levels than the latanoprost and bimatoprost groups. All medicines significantly lowered 24-h IOP from baseline (P = 0.001 for each). Although there was no significant difference in IOP reduction among groups at first week and first month, bimatoprost reduced the 24-h IOP (7.9 ± 1.4) more than travoprost (6.6 ± 0.5) at the end of the third month (P = 0.003). The mean 24-h range of IOP was lowest with travoprost in all visits, and between-group differences was significant for travoprost vs latanoprost (P = 0.007) and travoprost vs bimatoprost (P = 0.001) at the third month.

Conclusion. Latanoprost, travoprost, and bimatoprost were effective in reducing the 24-h IOP in patients with XFS and OH, and more research is required with a larger study.

Keywords: exfoliation syndrome; 24-h IOP; latanoprost; travoprost; bimatoprost.


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Hepsen I, Ozkaya E. 24-h IOP control with latanoprost, travoprost, and bimatoprost in subjects with exfoliation syndrome and ocular hypertension. Eye. 2007;21:453–8.

Translation from English.

Republished: September 2018