- Written by Super User
- Category: #2 (02) 2015
- Published: 29 January 2016
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SUMMARY
Objective. To evaluate the efficiency of 0.005 % latanoprost / 0.5 % timolol maleate fixed combinations, compared with 1 % brinzolamide / 0.5 % timolol maleate in patients with primary open-angle glaucoma (POAG).
Methods. In this study 50 eyes of 30 patients with POAG were examined. Fifteen patients (25 eyes) were appointed instillation by 1 % brinzolamide / 0.5 % timolol maleate (AZARGA, Alcon) within 1 month, then without a break in the treatment they were switched to 0.005 % latanoprost / 0.5 % timolol maleate (LANOTAN-T, Farmak) also for 1 month. Patients of the second group opposite at the beginning of treatment were appointed instillation by 0.005 % latanoprost / 0.5 % timolol maleate, and after 1 month were switched to the instillation of 1 % brinzolamide / 0.5 % timolol maleate.
Complex examination in addition to general ophthalmological methods included computer static perimetry and computer sphygmography.
Results. The appointment of a fixed combinations of 0.005 % latanoprost / 0.5 % timolol maleate and 1 % brinzolamide / 0.5 % timolol maleate provides a clinically significant decrease in intraocular presure from baseline level by 31 and 32 %, respectively.
It has been found that the combination of 0.005 % latanoprost / 0.5 % timolol maleate has more expressed neuroprotective effects compared with 1 % brinzolamide / 0.5 % timolol maleate due to improvement of microcirculation.
Keywords: primary open-angle glaucoma, fixed combinations of antihypertensive drugs.
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05.08.2015