Rafalyuk S.Y.
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine

SUMMARY

Introduction. Keratitis in patients with dry eye syndrome is well-known and not easy problem in ophthalmology.

Purpose. To explore the possibility of correction of metabolic disorders in the cornea during endotoxin-induced keratitis (EK) in animals with dry eye syndrome (DES).

Methods. Experiments were provided on Chinchilla rabbits, which were divided into 3 groups according to the tasks.

Results. The use of Lipoflavon (quercetin) under development of EK in animals with DES has a strong positive effect on the degree of inflammatory signs in the cornea, which were most pronounced during the second period of observation (48 hours). Instillation of quercetin reduced the degree of pathochemical violations in the anterior segment of the eye with tissue in animals with dry eye syndrome, and endotoxin-induced keratitis: the reduction of potential of the glutathione system, abnormal inflammatory process in the development of EK in animals with DES are largely unable to adjust without bioflavonoid – quercetin.

Conclusion. The clinical and experimental data revealed that the use of Lipoflavon (quercetin) result in correction of violations of pathochemical sings of EK with DES.

Keywords: keratitis, dry eye syndrome, glutathione, cornea, conjunctiva, tears.

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02.06.2015