Leus N. F., Al Dahdouh M.

GI “The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine”, Odesa, Ukraine

 Abstract

Introduction. The issue of efficiency of treatment of the senile cataract is one of the important issues in ophthalmology. The study is of particular importance in patients on background of glaucomatous process.

 Purpose. The purpose was to study the processes of lipid peroxidation in the lens and chamber moisture in modeling age-related cataract in experimental ocular hypertension.

 Methods. The studies were conducted on 39 rabbits which were divided into three experimental groups. The first group (9 animals) provided experimental simulation of the light cataract; the second group (8 animals) provided experimental modeling of the ocular hypertension; third (10 animals) was a group of combination of the light exposure and hypertension.

 Results. It was found the differences in the characteristics of peroxidation in the lens material and in the fluid of anterior chamber in the groups of animals with ocular hypertension and experimental age-related cataracts. We revealed more expressed intensification of lipid peroxidation in the lens of experimental animals with ocular hypertension and simultaneous exposition of light energy.

 Conclusions. Raised intraocular pressure significantly increase the intensity and terms of cataract development in the corresponding groups of experimental animals.

 Keywords: ocular hypertension, age-related cataracts, malondialdehyde, conjugated diene, lens, chamber moisture. 

REFERENCES

1. Alekseev V. N., Martynova E. B., Sadkov V. I. Peroxidation role in the pathogenesis of primary open angle glaucoma. Oftalmologicheskiy zhurnal [Journal of ophthalmology]. 2000; (1): 12–17 (in Russian).
2. Babizhaev M. A., Shvedova A. A., Archipenko Y. V. Accumulation of lipid peroxidation products in cataract lens. Byulleten eksperimentalnoy biologii i meditsiny [Bulletin of experimental biology and medicine]. 1985; (9): 299–301 (in Russian).
3. Veselovskaya Z. F., Bobrova N. F., Vit V. V. Cataract. Kyiv, Kniga plyus, 2002, 208 p. (in Russian).
4. Kravchuk E. A. Role of free radical oxidation in the pathogenesis of eye diseases. Vestnik oftalmologii [Bulletin of ophthalmology]. 2004; (5): 48–51 (in Russian).
5. Kurysheva N. O., Fedorov A. A., Urich V. I. Pathological features of cataract lens in patients with glaucoma. Vestnik oftalmologii [Bulletin of ophthalmology]. 2000; 116 (2): 13–16 (in Russian).
6. Leus M. F., Metelіtsina I. P., Drozhzhіna G. I. Method of modeling the lights cataract. Patent UA, no. 20178, 1997 (in Russian).
7. Leus N. F., Al Dahdouh M. Features of development of experimental forms of senile cataract in ocular conditions. Oftalmologicheskiy zhurnal [Journal of ophthalmology]. 2015; (3): 91–95 (in Russian).
8. Miheytseva I. Lipid peroxidation in experimental glaucoma adrenaline. Oftalmologicheskiy zhurnal [Journal of ophthalmology]. 1989; (7): 427–428.
9. Rebrov O. Statistical analysis of medical data. The use of the application package STATISTICA. Moscow, Media Sphera, 2002, 312 p. (in Russian).
10. Serdyuk V. N., Semenko V. V. Effect of light irradiation on the state of lipid peroxidation in the tissues of the eye in the modeling of primary glaucoma. Oftalmologicheskiy zhurnal [Journal of ophthalmology]. 2011; (1): 65–68. (in Russian).
11. Babizhayev M. A., Deyev A. I., Yermakova V. N., Brikman I. V. Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes. Drugs RD. 2004; (5): 125–139.
12. Bergmeyer H. V. Metoden der enzymatischen Analyse. Berlin, Herausgegeben von H. U. Bergmeyer, 1986, 2220 p.
13. Chandrasekaran S., Cumming R. G. Association between elevated intraocular pressure and glaucoma, use of glaucoma medications, and 5-year incident cataract: the Blue Mountains Eye Study. Ophthalmology. 2006; (113): 417–424.
14. Shaffer R. N., Rosenthal G. Comparison of cataract incidence in a normal vs a glaucomatous population. Transactions of the American Ophthalmological Society. 1969; (67): 369–373.
15. Wang Y. Y. Experimental study of carbomer glaucoma model in rabbits by injecting different location in anterior chamber. Ophthalmology. 2009; (45): 1–95. 

Received: 6 Nov. 2015

Published: April 2016