Efficiency of 0.005 % latanoprost / 0.5 % timolol maleate fixed combinations, compared with 1 % brinzolamide / 0.5 % timolol maleate in patients with primary open-angle glaucoma

Zavhorodnia N.H.^1, 2, Bezdenezhna O.O.^1, 2, Bezdenezhnyi S.V.^2
1SI «Zaporizhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine», Zaporizhia, Ukraine
²Clinic of Modern Ophthalmology «Visus», Zaporizhia, Ukraine

SUMMARY

Objective. To evaluate the efficiency of 0.005 % latanoprost / 0.5 % timolol maleate fixed combinations, compared with 1 % brinzolamide / 0.5 % timolol maleate in patients with primary open-angle glaucoma (POAG).

Methods. In this study 50 eyes of 30 patients with POAG were examined. Fifteen patients (25 eyes) were appointed instillation by 1 % brinzolamide / 0.5 % timolol maleate (AZARGA, Alcon) within 1 month, then without a break in the treatment they were switched to 0.005 % latanoprost / 0.5 % timolol maleate (LANOTAN-T, Farmak) also for 1 month. Patients of the second group opposite at the beginning of treatment were appointed instillation by 0.005 % latanoprost / 0.5 % timolol maleate, and after 1 month were switched to the instillation of 1 % brinzolamide / 0.5 % timolol maleate.

Complex examination in addition to general ophthalmological methods included computer static perimetry and computer sphygmography.

Results. The appointment of a fixed combinations of 0.005 % latanoprost / 0.5 % timolol maleate and 1 % brinzolamide / 0.5 % timolol maleate provides a clinically significant decrease in intraocular presure from baseline level by 31 and 32 %, respectively.

It has been found that the combination of 0.005 % latanoprost / 0.5 % timolol maleate has more expressed neuroprotective effects compared with 1 % brinzolamide / 0.5 % timolol maleate due to improvement of microcirculation.

Keywords: primary open-angle glaucoma, fixed combinations of antihypertensive drugs.

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