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Adenoviral eye diseases: etiology, diagnosis, clinical features and treatment

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Details: Published: Monday, 04 April 2016 11:50; Written by Super User; Hits: 2051

Sakovych V.M.
SE «Dnipropetrovsk Medical Academy of Health Ministry of Ukraine», Dnipropetrovsk, Ukraine

Summary. The article focuses on modern approaches to diagnosis and treatment of adenovirus eye injuries; the analysis of the main methods of diagnosis of adenoviral lesions of the vision and the therapeutic efficacy of the main groups of drugs used in the treatment of such patients. Ineffective treatment of acute adenoviral eye lesion leads to a transition of the process into the chronic form. The disease takes a long lax period, with short periods of remission and frequent relapses, which significantly reduces the quality of the patient’s life and delivers long-term. The ubiquity of adenovirus infection, its highly contagious character, loss of able to work population, the development of corneal complications with decreased visual acuity; all of this forced us to look for new approaches to the treatment of this disease. The results presented in the literature works showed that probiotics are more promises and effective method of treatment of adenoviral infections of the eye, as well as the need to find new ways and effective methods and means of treatment of adenoviral eye infections with the deeper research in this area.

Keywords: adenovirus eye diseases, methods of diagnosis and treatment.

State of thiol system in retina and optic nerve in modeling open-angle glaucoma (hypertension) in animals with streptozotocin diabetes

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Details: Published: Monday, 04 April 2016 09:06; Written by Super User; Hits: 1760

Yurevych V.R.
Danylo Halytsky Lviv National Medical University, Lviv, Ukraine

SUMMARY

Introduction. Relevant is the search of drugs aimed at the normalization of metabolic processes in the tissues of the eye in diabetes and hypertension.

Purpose. Examine the condition of the thiol in the retina and optic nerve for modeling open-angle glaucoma (hypertension) in animals with streptozotocin diabetes.

Methods. Studies were conducted on 34 rabbits. Experimental animals were divided into four groups: the first – the control group (10 rabbits), the second – experimental group, animals with diabetes in conditions of hypertension (8 rabbits), the third – the experimental group, animals with diabetes (8 rabbits), the fourth – the experimental group animals with hypertension (8 rabbits). In isolated tissues of the retina and the optic nerve was performed determination of the oxidized, reduced glutathione, as well as the level of thiol and disulfide groups of proteins.

Results. These disorders thiol status of neural tissue in the simulation open angle glaucoma diabetic animals reflect a high degree of oxidative stress and the reduction potential of the reducing and detoxification system of glutathione in the tissue of the optic nerve and retina.

Conclusion. In terms of modeling the experimental glaucoma (hypertension) in animals with streptozotocin diabetes showed a sharp drop in glutathione redox potential of the system in the neural cells of the body. The development of experimental hypertension in diabetic animals accompanied by a reduction of the thiol groups of 34.5 %, and increasing disulfide bond content of 29.7 %. These disorders thiol status of neural tissue in the simulation open angle glaucoma diabetic animals reflect a high degree of oxidative stress and the reduction potential of the reducing and detoxification system of glutathione in the tissue of the optic nerve and retina.

Keywords: hypertension, diabetes, glutathione, thiol, disulfide groups, proteins.

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Adenoviral eye diseases: etiology, diagnosis, clinical features and treatment

State of thiol system in retina and optic nerve in modeling open-angle glaucoma (hypertension) in animals with streptozotocin diabetes

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