Activity of lipid peroxidation processes in the tissues of the anterior eye with modeling hypothyroidism
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- Published: Sunday, 31 January 2016 18:23
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SUMMARY
Introduction. The problem of ocular manifestations of primary hypothyroidism is relevant for ophthalmology in both practical and scientific standpoint.
Purpose. Explore the lipid peroxidation in the cornea, conjunctiva and lacrimal fluid with hypothyroidism.
Methods. The studies were conducted on rats, which divided into 3 groups: I group – control (14 rats), II group – experimental (14 rats), animals with mild (primary) form of hypothyroidism, III group – experimental (14 rats), animals with severe form of hypothyroidism. In the tissues of the cornea and conjunctiva and lacrimal fluid content determined malondialdehyde and diene conjugates.
Results. Hypothyroidism observed dysregulation of lipid peroxidation and antioxidant system, which eventually leads to a state of oxidative stress, which is known to adversely affect the function and protective-adaptive mechanisms of eye tissue.
Conclusion. It is established that in the experimental hypothyroidism increases the level of lipid peroxidation products in the tissues of the conjunctiva and cornea, with a particularly significant increase in malondialdehyde noted in the conjunctiva (70.5 % – in the mild stages, 85.6 % – in severe stage hypothyroidism). It was found that when in the tear fluid hypothyroidism increases in malondialdehyde concentration 1.5 times – during the mild stage of hypothyroidism and 1.65 times – in severe stages. This pathochemical index can be considered as a diagnostic sign of the state of oxidative stress in the body of hypothyroidism in the initial stages of its development.
Keywords: hypothyroidism, tears, cornea, conjunctiva, malondialdehyde, diene conjugates, experiment.